Sulforaphane is an incredibly hard molecule to make stable at room temperature. It just wants to fall apart immediately. That's why every company takes a different approach to formulating it. Our approach is one of a kind: we focus on making the highest quality precursor molecules. We grow the ingredients that make sulforaphane.

We make sure they are of the highest quality possible and mix them in the right proportion so all you have to do is add some fruit juice or sparkling water.

We let you activate it so the most sulforaphane possible is produced.

Sulforaphane is a defensive molecule plants make to protect them from predators chewing their leaves.

It forms naturally when the walls of a plant's cells are torn, like when it's being eaten, and two molecules are mixed in the saliva. It's a spicy molecule and tends to thwart further eating. Sulforaphane is basically the reason that foods like broccoli, brussel sprouts and coliflour are considered healthy. They contain the ingredients to make sulforphane.

The challenge is in getting both molecules into your diet at the same time. It's not easy and it requires eating a great deal of things like broccoli.

As a beautiful fluke of evolution, however, there is a bacteria in our gut that produces the enzyme myrosinase. This would allow us all the simply eat broccoli and know we're making some sulforaphane.

The problem, however, is the ever increasing prevalence of pesticides, herbicides, and fungicides that destroy our gut micribiome.

So knowing how much myrosinase you can produce versus anyone else is almost impossible to know without extensive lab testing.

This is why we include every molecule needed to produce incredibly potent, all natural sulforaphane in our brocclean product line.

Ok, you got sulforaphane into your system. What does it actually do? This is where things get truly wild.

Sulforaphane unleashes a system in your body called the NRF2 Signaling Pathway. It's defense mechanism that body has to remove molecules that don't belong, and repair the damage they caused.

It activates over 60+ parts of your DNA that focus removing chemicals from different parts of your body. It's these genes that cause all the beneficial findings in over 3,000 scientific experiments. Because it's own body doing the work, it's done precisely and gently. The only side effects of sulforaphane are an upset stomach from taking too much.

Since your own genes are getting activated in the end, the array of benefits sulforaphane provides is wide sweeping.

Among the many benefits, there is a clear ability for sulforaphane to reduce bmi and weight in a healthy manner.

Here's a summary of key findings:

Effects on Body Weight and Fat Mass

SFN has demonstrated significant effects on reducing body weight and fat mass in obese mice:

• In diet-induced obese (DIO) mice, a 2-week treatment with SFN (5 mg/kg daily) led to an 18.2% reduction in initial body weight, compared to only 4.8% in the control group[1][2].
• SFN supplementation resulted in a weighted mean difference (WMD) of -2.76g in body weight across multiple studies[3].
• SFN treatment reduced liver weight, with a WMD of -0.93g[3].
  

Impact on Food Intake and Metabolism

SFN appears to influence weight loss through multiple mechanisms:

• It significantly decreased food intake in DIO mice[1][2].
• SFN lowered the respiratory exchange ratio (RER), indicating increased fat utilization and fatty acid oxidation[1][2].
• It suppressed the expression of fatty acid synthesis genes in the liver and white adipose tissues[1][2].

Effects on Lipid Profile

SFN showed beneficial effects on serum lipid levels:

• Total cholesterol: WMD of -15.62 mg/dL
• LDL cholesterol: WMD of -8.35 mg/dL
• Triglycerides: WMD of -40.85 mg/dL
• HDL cholesterol: No significant effect (WMD of 1.05 mg/dL)[3]

Mechanism of Action

Research suggests that SFN's anti-obesity effects work through several pathways:

• It activates the NRF2 transcription factor, which regulates redox homeostasis and inflammation resolution[1][2].
• SFN requires functional leptin receptor signaling and hyperleptinemia for its weight-reducing effects[1][2].
• It promotes the browning of white adipose tissue and enhances mitochondrial biogenesis[4].

Dosage and Administration

In animal studies:

• Effective dosages ranged from 0.5 mg/kg to 30 mg/kg[3].
• Administration routes included oral, subcutaneous, and intraperitoneal injections[3].
• Treatment durations varied from 3 to 16 weeks[3].
  
  These findings suggest that SFN could be a promising compound for weight loss and obesity management. However, it's important to note that most of these studies were conducted in animal models, and further research is needed to confirm these effects in humans.

Citations:
[1] https://pmc.ncbi.nlm.nih.gov/articles/PMC8947770/
[2] https://elifesciences.org/articles/67368
[3] https://www.nature.com/articles/s41598-021-87367-9
[4] https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.665894/full
[5] https://www.foundmyfitness.com/news/s/ttwfpw/sulforaphane_found_in_broccoli_sprouts_causes_20_fat_loss_by_changing_gut_bacteria_increasing_mitochondria_in_fat_in_mice/comments/tvf2h7
[6] https://pmc.ncbi.nlm.nih.gov/articles/PMC6261473/
[7] https://www.mdpi.com/2304-8158/13/7/1055
[8] https://www.sciencedirect.com/science/article/pii/S075333222200662X